Autoimmune hemolytic anemia (AIHA) occurs when antibodies directed against the person’s own red blood cells (RBCs) cause them to burst (lyse), leading to. Autoimmune hemolytic anemia (AIHA) is an uncommon disorder characterized by hemolysis mediated by autoantibodies directed against. Autoimmune hemolytic anemia is characterized by shortened red blood cell survival and a positive Coombs test. The responsible autoantibodies may be either.

Author: Tauran Zololl
Country: Monaco
Language: English (Spanish)
Genre: Personal Growth
Published (Last): 15 October 2013
Pages: 305
PDF File Size: 11.91 Mb
ePub File Size: 6.4 Mb
ISBN: 990-4-67383-405-4
Downloads: 64097
Price: Free* [*Free Regsitration Required]
Uploader: Voodookazahn

Fatal immune hemolytic anemia due to cefotetan. Salama, with kind permission of the patient. However, transfusion should not be withheld in a critically ill patient even in the absence hemooitik compatible blood.

Anemia Hemolitik Autoimun

Increased unconjugated bilirubin is characteristic of hemolytic anemia. Applied Blood Group Serology; pp. New insights into childhood autoimmune hemolytic anemia: About 20 years later, Hayem distinguished between congenital hemolytic anemia and zutoimun acquired type of infectious icterus associated with chronic splenomegaly.

Some cases of drug-induced immune hemolytic anemia also exhibit a positive DAT only with an anti-complement reagent.


Children with chronic AIHA tend to be older [ 60 ]. This page was last edited on 25 Octoberat Clinical and serological characterization of autoimmune hemolytic anemia in a tertiary care hospital in North India. It is more common in women than in men [ 23 ]. Immunochemical studies on blood groups: Clinico-hematological spectrum of 79 cases.

Hereditary aspects of autoimmune hemolytic anemia; a retrospective analysis. Most of the etiology of AIHA warm type was idiopathic or primary Most cases of PCH are self-limited.

Aytoimun was observed by Sokol et al. Although RBC transfusion is not a contraindication in AIHA, however its use should be limited to cases of life-threatening anemia or a high risk of cardiac or cerebrovascular ischemic events.

Autoimmune hemolytic anemia

In these patients, one tends to see antibodies with lower thermal amplitude requiring more severe chilling for the agglutinin to bind to RBCs. Splenomegaly, a characteristic finding in lymphoproliferative diseases or infectious mononucleosis, may be observed in idiopathic cold agglutinin disease.

Summary Autoimmune hemolytic anemia is characterized by shortened red blood cell survival and a positive Coombs test. Drug-induced AIHA is serologically indistinguishable from warm AIHA; a presumptive diagnosis can be made only if the patient aealah to withdrawal of the drug.


Autoimmune hemolytic anemia – Wikipedia

Journal List Blood Res v. Clinical history is also important to elucidate any underlying illness or medications that may have led to the disease.

Hemolysis must also be demonstrated in the lab. Clinical Medicine 6th ed.

Methyldopa-induced auto-immune haemolytic anaemia-a report of two further cases. RBC transfusion would be an effective supporting treatment option as a bridge therapy. The variability of hemolysis in the cold agglutinin syndrome.

Autoimmune hemolytic anemia associated with anti-Sc 1. Autoimmune hemolytic anemia and paroxysmal nocturnal hemoglobinuria.

The Clinical Pictures of Autoimmune Hemolytic Anemia

These hemolytic episodes were thought to be due to infectious agents. A century of exciting progress in understanding. Patients with more severe disease symptomatic anemia, transfusion dependence may be treated with rituximab.

The clinical picture is quite variable.